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New Challenges and Opportunities for AgNP: Virus

It takes many studies and applications within the laws of each country, so that we can state that an agent has or not action under a particular group of pathogens, be they viruses, fungi or bacteria. We can not empower false research ( "research" not specified) for fear of still not sure or knowledge of the treatment of any disease.

Already exist in the literature studies that point to a promising advance the use of silver nanoparticles (AgNps) In multiple markets. Many successful attempts have been made in the study of the role of inhibition of AGNPS in virus growth, such as influenza virus, herpes simplex type 1 and type 2 (HSV-1 e HSV-2), vírus tacaribe Coxsackievirus B3 (TCRV), Vaccinia virus (VACV), human parainfluenza virus type 3 (HPIV-3), hepatitis B virus (HBV) And varicella (MPV). However, the exact mechanism for the action of these nanoparticles is still little known. But it is reported in the literature that the smaller the size of the largest AGNPS is the effectiveness of inhibition. Table 1 shows some applications of silver nanoparticles with potential application in combating viruses.

Table 1 - Potential applications of AgNp from virus checks

AgNps estabilizadas com mercaptoetanossulfonato por exemplo, inibem a infecção pelo HSV-1 porque ajudam a evitar a ligação do vírus a células hospedeiras e, desse modo, a entrada do vírus nas células. Outro motivo é que as AgNps funcionalizadas com mercaptoetanossulfonato têm a capacidade de imitar o sulfato de heparano (receptor primário celular do HSV) e, portanto, essas AgNps passam a competir com o vírus pela ligação na célula.

A eficácia antimicrobiana das AgNps tem sido amplamente analisada durante a última década, mas a demonstração de sua atividade contra vírus como uma arma potencial é recente. De fato, AgNps podem ser ativas contra uma ampla gama de vírus, com a possibilidade ainda de apresentarem uma menor possibilidade de desenvolver resistência em comparação aos antivirais convencionais. As nanopartículas têm um forte potencial antiviral e, devido às suas múltiplas interações com os receptores de glicoproteínas, podem inibir a multiplicação viral dentro da célula hospedeira, impedindo a replicação ou bloqueando a entrada das partículas virais no interior da célula hospedeira.

Contamination Host

It is known that viruses, such as obligate intracellular parasite infection has its amplified form through their placement with bacteria and other microorganisms. In this context, TNS has in its portfolio a unique range of products for antibacterial treatment, which help control and spread of viruses that use bacteria as hosts, increasing the range of propagation.

In conclusion, silver nanoparticles may have different properties as a result of its production method (size, shape, binding agent and level of dispersion), and further studies are warranted to elucidate its mechanism of action, which makes it possible to exploit this nanomaterial in the clinical setting against viral infections.

The TNS points out that there are few published studies on the use of silver nanoparticles in combating Covid-19.

By Alexsandra Valerio
[email protected]
References / table Source:
[1] [2] [3] [4] [5] [6] [6] [7] [8]